South Dakota State Highway 281displays an excellent two lane highway which extends from Canada to Mexico. A travel vacation following this state highway from beginning to end will cross through the heartland of the Midwest traveling through the mid states to the Mexico border. Highway 281 in South Dakota shows the many changing facets of the landscapes; the lakes and farmlands on the North Dakota line to the rolling bluff along the Missouri River on the Nebraska state line.

Just click on a city below.to begin exploring this beautiful and exciting state!